Shigihara N Iodine concentrations in breast milk and infant urine were measured on the same day. , , , , , Mandel SJ We speculate that infants in regions characterized by low iodine intake and iodine deficiency might be more strongly affected by iodine overload. , Kogai T In: Endocrine Abstracts. The Wolff–Chaikoff effect is a presumed reduction in thyroid hormone levels caused by ingestion of a large amount of iodine.. Because the Wolff–Chaikoff effect is generally transient in the normal thyroid, thyroid hormone synthesis would normalize within a few days because of the so-called escape phenomenon [19]. This is achieved by decreasing the intrathyroidal inorganic iodine concentration by down regulation of the sodium iodine symporter ... Hyperthyroidism in patients with ischaemic heart disease after iodine load induced by … , It is reported that in some cases, long-term control of thyroid function as well as remission of Graves disease can be achieved with inorganic iodine alone [3, 4]. However, inorganic iodine is transferred to fetuses via the placenta and to infants via breast milk [5]. For more than 100 years high doses of iodine have been known to benefit both underactivity (hypothyroidism) of the thyroid gland and overactivity of the thyroid gland (hyperthyroidism). Thyroid-stimulating hormone (TSH) deficiency. This study also evaluated breast milk and infant urine iodine concentrations. It was discovered by Drs. Sato J , , , However, inorganic iodine therapy appears to be a potentially useful alternative for mothers with Graves disease with adverse reactions to antithyroid drugs who are contraindicated for iodine-131 therapy because they wish to continue breastfeeding (due to the superiority of breast milk to formula or due to infant rejection of formula) and do not wish to undergo surgery. , Wolff J In case 15, the blood TSH level was 5.5 μIU/mL at 3 months after birth; however, we were unable to follow this case. Grobman WA , , Laurberg P Chen H The study protocol was approved by our clinical Institutional Review Board. Iodine-Containing Compounds. , , 1). The maturation of thyroid function in the perinatal period and during childhood. Her only additional iodine intake was the salt she used for cooking. Some of the symptoms of hyperthyroidism include nervousness, irritability, increased perspiration, heart racing, hand tremors, anxiety, trouble sleeping, thinning of the skin, fine brittle hair, and muscular weakness—especially in the upper arms and thighs.More frequent bowel movements may occur, and diarrhea is common. IODINE AND INORGANIC IODIDES: HUMAN HEALTH ASPECTS First draft prepared by John F. Risher and L. Samuel Keith, United States Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, Georgia, USA Published under the joint sponsorship of the United Nations Environment Programme, the The thyroid hormone response to salt removal suggested a salt influence upon the development of hyperthyroidism. COVID-19 is an emerging, rapidly evolving situation. , , , Honda A Inorganic iodine decreases serum thyroid hormone concentrations in patients with Graves' hyperthyroidism without adverse reaction, but this effect usually continues only a limited time. The median KI dosing periods were 9 months (range, 1 to 78 months) from before through after delivery and 2 months (range, 1 to 9 months) after delivery. Hamada K Iodine concentrations in breast milk correlated significantly with those in infant urine, and KI doses correlated with breast milk and infant urine iodine concentrations, which strongly suggests that the KI administration to lactating mothers contributed to iodine overload in the study infants through breast milk. Arrows indicate data from the same cases. IV.  |  Effect of inorganic iodine compounds and of di-iodotyrosine on uncomplicated hyperthyroidism and experimental Graves' disease. By extension, they were sometimes used to treat Graves' disease, but by the end of the century, they were considered to be a dangerous form of therapy. Peeters RP We have devised two explanations for this outcome. Fukata S . , Anzo M The Mann-Whitney U test was used for statistical comparison, and the Spearman rank correlation coefficient was used to evaluate correlations. , In other words, thyroid function might have normalized after transient hypothyroidism. Brown RS Walter MA Inorganic iodine therapy may become one of the treatment methods in the patients with mild Graves' hyperthyroidism. However, They advocate a nutritional supplement program prior to using Iodine: Selenium. The iodine-containing compounds used in the treatment of hyperthyroidism are potassium iodide (KI) in the form of KI tablets, a saturated solution of potassium iodide (SSKI), and Lugol’s solution. , Nowadays, patients with Graves' hyperthyroidism are initially treated with methimazole or propylthiouracil. We note that the study setting of Japan, where dietary iodine intake is sufficient, may have buffered the effects of excess iodine exposure. 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