Additional molecular and clinical studies investigating this compound are needed in order to find out an effective intervention. Silymarin has been said to be at least ten times more potent in antioxidant activity than vitamin E. 10 11 12; It increases glutathione in the liver by more than 35% in healthy subjects and by more than 50% in rats. Polyphenols present in silymarin. El-Sherbiny et al. 65 It is a mixture of flavonolignans, consisting of silibinins A and B, isosilibinins A and B, silicristin, and silidianin 65 (Fig. Current studies have demonstrated that silymarin inhibits melanoma cell migration by reducing MMP-2 as well as MMP-9 protein levels (Vaid et al., 2011). The side effects that are associated with using this medication are rare. In addition, silymarin also acts on the immune system stimulating IL-12 to increase its levels, thereby protecting cells from UV-induced damage (Meeran et al., 2006). It is known, though, that silymarin is innocuous. Silymarin was well tolerated in chronic HCV-infected patients, but there was no evidence of positive effects for oral silymarin, although intravenous silybin did show some benefits.25, Elroy Saldanha, ... Manjeshwar Shrinath Baliga, in Dietary Interventions in Gastrointestinal Diseases, 2019, Silymarin isolated from the milk thistle (Silybum marianum) is arguably the most commonly used medication for various liver diseases.65 It is a mixture of flavonolignans, consisting of silibinins A and B, isosilibinins A and B, silicristin, and silidianin65 (Fig. Among the primary signs of Metabolic Syndrome are elevations in serum triglycerides and bad cholesterols, in the form of VLDL and LDL cholesterol, and reductions in the good cholesterol, HDL. There are studies that suggest that silymarin can inhibit the synthesis of VLDL and LDL cholesterol233, lower triglycerides, and increase HDL234. Copyright © 2020 Elsevier B.V. or its licensors or contributors. There was a reduction in indirect bilirubin among those assigned to silymarin, but other variables, including direct bilirubin, ALT, and AST, were not significantly reduced.23, In a study of chronic viral hepatitis, silymarin was shown to result in dramatic improvement. Silymarin, the active component of milk thistle, contains four flavolignans.29 The most remarkable is silybin (up to 70%), which is an antioxidant, consumes free radicals, and inhibits lipid peroxidation. Here are some links to Top selling Milk Thistle Suppliments: 1. Silymarin appears to reduce inflammation, which is a major component of Metabolic Syndrome. Common symptoms of hepatitis (e.g., abdominal discomfort, decreased appetite, and fatigue) were all improved.24, Silymarin has been studied in hepatitis C, with little evidence of efficacy. Scott D. Mendelson M.D., Ph.D., in Metabolic Syndrome and Psychiatric Illness, 2008. Jeho liečivé účinky boli známe už v starom Grécku. Most of the volunteers receiving silymarin had improved levels of hemoglobin and erythrocyte sedimentation rate. Mechanism of Action of Silymarin Silymarin stimulates RNA polymerase A and results in an increase in ribosomal protein synthesis and leads to the synthesis of new hepatocytes and also increase the regenerative ability of the liver. Camila S. Silva PhD, ... Helio Vannucchi MD, PhD, in Molecular Aspects of Alcohol and Nutrition, 2016, Silymarin is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Oil-based nanocarrier for silymarin improved the oral efficacy of silymarin in vitro and in vivo studies exhibiting hepatoprotection (Parveen et al., 2011, p. 245). Used at a high dose (420 mg) for periods of 3 to 12 months, silymarin resulted in a reversal of liver cell damage (as noted on biopsy), a rise in protein level in the blood, and a lowering of liver enzyme values. 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